It also has been shown that overexpression of PDGF-D increases migration and invasion of pancreatic cancer cells through matrigel and induces tube formation of human umbilical vein endothelial cells (HUVECs) with the resultant activation of matrix metalloproteinase-9 (MMP-9) and VEGF. The gene discussed is MMP9; the disease is familial pancreatic carcinoma.