Using a Lewis lung adenocarcinoma (LLC) transplantation model we have further demonstrated that mastic oil (45 mg/kg body weight, i.p., every other day for about three weeks) can significantly limit tumor expansion in syngeneic mice without toxicity, by targeting in vivo cancer cell apoptosis, tumor-associated neovascularization and inflammation, in part through negative modulation of Ras/RhoA GTPases and NF-kappaB-dependent gene transcription [23]. The gene discussed is RHOA; the disease is neoplasm.