Finally, in line with the role of COUP-TFs in angiogenesis during development, both COUP-TFI and COUP-TFII together with orphan receptor hepatocyte nuclear factor 4α (HNF-4α) are potent activators of VEGF-D expression in MKN-45 gastric carcinoma cell line [38] and in MCF-7 cell line [49], suggesting these factors impact cancer progression by promoting neo-angiogenesis and lymphangiogenesis. The gene discussed is NR2F2; the disease is cancer.