PRKCA and malignant colon neoplasm: For example, overexpression of PKCα has been demonstrated in tissue samples of prostate, endometrial and high-grade urinary bladder [43,44], up-or down-regulation of PKCα has been observed for hematological malignancies [45] while down-regulation of PKCα has been described in basal cell carcinoma and colon cancers [46,47].