Dealing with intracellular signalization in H295R cancer cells, they additionally reported that the protein functioned as an activator of cell cycle, releasing cells from G1/S checkpoint and consequently increasing the number of cells in the S and G2/M phases, and that PTHrP produced its action via two signaling pathways, intracellular cAMP/protein kinase A and Ca++/phospholipase C. Moreover, a positive correlation between protein production and steroid secretion was also proven. This evidence concerns the gene PTHLH and cancer.