PTHLH and squamous cell lung carcinoma: In 1990, Burton and collaborators [24] reported the growth stimulatory effect of PTHrP (1–34) on BEN squamous cell lung carcinoma cells in vitro, whereas in 2001, Hastings and co-workers [25] demonstrated that the peptide inhibits the growth of the same cells and that exposure to anti-PTHrP antibody stimulated the growth of BEN cell carcinomas in athymic mice, thereby highlighting the paracrine growth inhibitory effects of N-terminal PTHrP fragment on lung tumor.