In Luparello and coworkers' paper in 2001 [19], cell viability, proliferation, invasiveness and growth in nude mice was examined following administration of the midregion (38–94) fragment of PTHrP, which was proven to reduce markedly breast cancer growth and invasion in vitro and in vivo, thereby representing an attractive target for molecular modeling of smaller, orally active anti-neoplastic agents. This evidence concerns the gene PTHLH and breast cancer.