PTHLH and colon adenocarcinoma: Interestingly, the PTHrP-mediated over-expression of α5 and β1 integrin subunits was reported in another colon adenocarcinoma cell line, HT-29, and found responsible for the increase of adhesion to extracellular matrix proteins (type I collagen, fibronectin), that was reverted by PTHrP silencing.