PTHLH and chondrosarcoma: In 2003, Miyaji and collaborators [35] were the first to investigate the effects of treatment with anti-PTHrP monoclonal antibodies on cell viability and differentiation of chondrosarcoma HTB-94 cells, finding that the treatment triggered apoptosis via, at least in part, imbalance of Bcl-2/Bax ratio, activation of caspase-3 and PARP cleavage, also accelerating cell differentiation to the hypertrophic chondrocyte stage.