In 2005, Dackiw and coworkers [36] reported that the farnesyl transferase inhibitor manumycin A, which is a microbial product, was active in both decreasing nuclear import of PTHrP and increasing proteasome-mediated PTHrP degradation by this tumor cytotype, and displayed an inhibitory and pro-apoptotic effect in vitro and in vivo. Here, PTHLH is linked to neoplasm.