HIF1A and familial pancreatic carcinoma: In conclusion, NT-NTR signaling in pancreatic cancer cells seems to promote the induction of a metastatic phenotype by activation of distinct stress-activated signal transduction pathways, generation of intracellular alkalinization/extracellular acidification, increased expression of IL-8 and possibly HIF-1α, in contrast to its varying effects on tumor cell proliferation.