For this purpose, we particularly analyzed the relative expression of NTR1 and EGFR in dependence of cell density and acidosis in vitro. We used a panel of pancreatic cancer cell lines and the colon carcinoma cell line HT-29, the original source for cloning of NTR, for comparison of effects of NT-induced signal transduction [9]. The gene discussed is NTSR1; the disease is familial pancreatic carcinoma.