In particular, the selective nonpeptide NTR1 antagonist SR 48692 was tested in a double-blind, randomized, phase II-III maintenance study versus placebo in patients with extensive stage small cell lung cancer following a first-line chemotherapy with cisplatin and etoposide (NCI identifier NCT00290953) and revealed only sporadic responses at best, which resulted in discontinuation of the development as an anticancer drug (Evaluation of the Overall Survival of Meclinertant Versus Placebo After a First Line Chemotherapy With Cisplatin + Etoposide; Clinical Trials, 2009) [18]. This evidence concerns the gene NTSR1 and small cell lung carcinoma.