In summary, since the overall benefit of radio- and chemotherapeutic treatment of pancreatic cancer is at present still regrettably low, the overview on the current experimental evidence of drug-induced alterations in relevant transporter expression and on the contribution of these specific cellular membrane factors towards chemoresistance stresses the importance of integrating the role of uptake and export transporters of the nucleoside and MRP families into strategies aimed at developing improved chemotherapies against pancreatic carcinoma. This evidence concerns the gene ABCC1 and exocrine pancreatic carcinoma.