If one takes into account the study by Fogt et al. [22], in which the hyperplastic polyps analyzed showed no loss of heterozygosity in the case of APC, and the report by Zauber et al. [25], in which no APC mutations were detected in serrated lesions, one must conclude that at the very early stage of colorectal carcinogenesis APC mutations are rare. This evidence concerns the gene APC and hyperplastic polyp.