MAP2K7 and colorectal carcinoma: Moreover, in a recent study by our group, in which CRC samples underwent a mutational analysis with the same oligonucleotide primer panel used in the present report, it was shown that 45% of mutation-positive CRC only exhibited alterations in the Wnt signaling cascade and 38% of mutation-positive CRC only exhibited alterations in the Ras-Raf-MEK-MAPK signaling cascade [20].