The results obtained in the present report also show that in about one third of the serrated lesions and adenomas analyzed neither the Wnt nor the Ras-Raf-MEK-MAPK signaling pathway are affected, thus suggesting that the above-mentioned lesions might develop along a pathway different from the so-called adenoma-carcinoma sequence [1-3], the serrated adenoma pathway [10-12,17], or the fusion pathway [14]. Here, MAP2K7 is linked to carcinoma.