In addition with the current routinely used markers such as HBV surface antigen (HBsAg), HBV extracellular antigen (HbeAg) and alanine aminotransferase (ALT), the circulating miRNAs represent a significant clinical value for better evaluation of the HBV-infection status, liver injury and early diagnosis of HCC. This evidence concerns the gene GPT and hepatocellular carcinoma.