Schurgers et al., measured dephosphorylated, uncarboxylated MGP (dp-ucMGP) in a cohort of 107 patients ranging from CKD stages 2-5D, and reported that levels of plasma dp-ucMGP increased progressively with CKD stage, indicating a decline in this biomarker with a reduction in GFR [11]. This evidence concerns the gene MGP and chronic kidney disease.