Moreover, many studies have demonstrated a negative correlation between RKIP protein and the metastatic ability of malignant tumors such as prostate cancer, breast cancer, colon cancer, melanoma, and adenocarcinoma, as well as the potential anti-cancer activity of RKIP protein, which would be a novel therapeutic target for cancer[7-14]. This evidence concerns the gene PEBP1 and malignant colon neoplasm.