POMC and obesity due to melanocortin 4 receptor deficiency: As hyperactivation of mTORC1 in POMC neurons leads to hyperphagia and obesity in mice (Mori et al., 2009), the increased phosphorylation of mTORC1 seen in the hypothalamus of Ksr2−/− animals (Revelli et al., 2011), may contribute to their increased food intake.