Multivariate Cox regression analysis confirmed cytosolic caspase-8 to be a survival predictor independent from tumor grading [G3 versus G1/2: HR = 2.28 (95% CI: 1.14-4.55), p = 0.0196 and cytosolic caspase-8 <2.8 versus ≥2.8: HR = 2.39 (95% CI: 1.16-4.92), p = 0.0182]. The gene discussed is CASP8; the disease is neoplasm.