CASP8 and neoplasm: Because of the strong correlation of nuclear expression of caspase-8 and tumor grading and the low number of patients with nuclear caspase-8 IRS ≥10.3, none of the two factors were significantly associated with survival in a multivariate Cox regression analysis [G3 vs G1/2: HR = 1.72 (95% CI: 0.85-3.49, p = 0.134 and nuclear caspase-8 ≥10.3 versus <10.3: HR = 1.80 (95% CI: 0.81-4.01)].