Enhancement of tumor cell migration and inhibition of Fas-induced apoptosis has been recently described as a non-apoptotic function of caspase-8 in different experimental cancer cell lines, which was not dependent on its catalytic activity but on Src-mediated phosphorylation of Tyr380 in a linker region between the small and large caspase-8 subunits [50,51]. This evidence concerns the gene CASP8 and neoplasm.