Many studies have demonstrated that PXR plays an important role in the clearance and elimination of toxic products of metabolism[3], however it has become clear that PXR also plays an important role in lipid metabolism as it was shown that PXR could increase fatty acid uptake by directly increasing the expression of the membrane bound fatty acid transporter (FAT, CD36)[4] PXR transgenic mice demonstrated hepatic steatosis[1]. Here, NR1I2 is linked to fatty liver disease.