Taking into account the fact that the high levels of ROS produced in cells due to the function of this enzyme could stimulate the transcriptional activity of the cancer-related transcription factor p53 [44] as well as that decreased CYP2E1 levels observed throughout cancer progression in different cancers [19,45] led us to explore the possibility that CYP2E1 was a possible p53 transcriptional target. Here, TP53 is linked to cancer.