A study on the role of alcohol metabolism in the pathogenesis of NASH found that the alcohol dehydrogenase genes, catalase genes, cytochrome P450 2E1 (CYP2E1) and aldehyde dehydrogenase have an increased level of transcription in NASH patients compared to controls [3]. This evidence concerns the gene CYP2E1 and metabolic dysfunction-associated steatohepatitis.