TGFB1 and Hepatic fibrosis: We have also observed increased enrichment of the histone modifications in the patient at the start of the genes for platelet derived growth factor (PDGF) and for transforming growth factor (TGFβ1), which are both known to mediate hepatic fibrosis, a well-known component of ASH [28] (Additional file 2: Figure S6D-E).