EDN1 and heart failure: Both echocardiographic parameters and expression data of well-known HF biomarkers (Nppa - natriuretic peptide A precursor, Nppb - natriuretic peptide B precursor, Edn1 - endothelin 1 [23,24]) supported the finding that only animals with large MI developed extensive LV remodelling and heart failure, while intermediate or small MI resulted in compensated LV injury.