Both echocardiographic parameters and expression data of well-known HF biomarkers (Nppa - natriuretic peptide A precursor, Nppb - natriuretic peptide B precursor, Edn1 - endothelin 1 [23,24]) supported the finding that only animals with large MI developed extensive LV remodelling and heart failure, while intermediate or small MI resulted in compensated LV injury. Here, EDN1 is linked to myocardial infarction.