We also show that ~95% depletion of c-KIT transcript levels by siRNA treatment (Figure 5B) rescued EGR1, VCAM1, CCL20, and IL-8 gene expression in response to Y. enterocolitica WA infection in THP-1 cells, compared to infected control cells treated with non-targeting siRNA (si-CTL) (Figure 5C). The gene discussed is KIT; the disease is infection.