CDH7 and Global developmental delay: Increasing dosage of CDH7 was proposed to be responsible for the recurrent pattern of MCA.<h4>Results</h4>High resolution array-CGH analysis identified a 4.2 Mb de novo interstitial duplication of the 8q12.1-q12.3 chromosome region in a boy with developmental delay, dysmorphic features, type 3 Duane anomaly.