Of 13 biomarkers analyzed, we find VEGF, cyclin D1, Ki-67, and SCC-Ag appeared to hold potential as predictors of outcome in ESCC; COX-2 and HER-2 in EADC; and p21, p53, CRP and Hb in EC. Here, GSTM1 is linked to esophageal squamous cell carcinoma.