The first case suffered from HCMV chorioretinitis, the one-day-old newborn presented with microcephaly and intracerebral calcification, the 10-day-old infant (HCMV IgM positive) suffered from hepatosplenomegaly and neonatal jaundice, while the 19-day-old infant (HCMV IgM positive) presented with cholestatic jaundice and neurological manifestation. Here, CD40LG is linked to Hepatosplenomegaly.