Patients' genetic asset could be either predisposing (HLADRB1*15, HLADRB1*16, DQB1*06 [23, 66], and HLA-A*31:01 [72] alleles, this latter for MTX-related ILD) or protective (HLA-DRB1 SE [66]) for the development of RA-ILD. This evidence concerns the gene HLA-DRB1 and rheumatoid arthritis.