As we previously described, interactions mediated by the cancer-associated TF glycoantigen and Gal-3 play an important role in several rate-limiting steps of cancer metastasis such as cell adhesion to bone marrow endothelium, homotypic tumor cell aggregation, and clonogenic survival and growth [34, 35], and it was only recently shown that Gal-3 influences bone metastasis in a mouse model after intracardiac injection of luciferase-expressing PC-3 cells in nude mice [39]. The gene discussed is LGALS3; the disease is cancer.