LGALS3 and posterior cortical atrophy: Indirect targeting of Gal-3 by using daily intraperitoneal administration of Lac-l-Leu, which binds and inhibits Gals by mimicking essential structural features of the TF-Ag, affects PCa cell adhesion to bone marrow endothelium, homotypic aggregation, transendothelial migration, clonogenic growth, and final spreading of tumor cells to the skeleton [39].