CD40LG and infection: Interestingly, we also detected higher IgM titers in IL-10−/− mice at the beginning of infection, which may also have limited disease progression, since it has been shown that IgM antibodies against a surface protein of H. capsulatum led to augmented phagocytosis and killing of this fungal pathogen by macrophages, diminished pulmonary inflammation and prolonged the survival of lethally infected mice [73].