Recent evidences linking impairment in the IL-12/interferon (IFN)-γ axis to susceptibility to disseminated PCM [23], [24], and the high levels of IL-10 detected in the severe forms of various mycosis [25]–[27], [1], [2], strongly indicate that IL-10 exerts deleterious effects on fungal infections. This evidence concerns the gene IL10 and paracoccidioidomycosis.