The role of GzmB in cardiovascular diseases has been a topic of increasing attention in recent years [32,43,44].Prf1-dependant, GzmB-mediated apoptosis has been the primary mechanism investigated in this regard and recent studies have suggested evidence of this pathway as an important mechanism in vulnerable plaque formation[32-34].While absent in the normal vessel and vessels with mild atherosclerosis, GzmB is abundant in vessels with advanced disease and GzmB expression is associated with increased disease severity and plaque instability[34]. The gene discussed is GZMB; the disease is atherosclerosis.