Nevertheless, differences in staining patterns were observed between the GzmB and Prf1 deficient animals, suggesting a specific GzmB-mediated effect on decorin in the plaques of ApoE KO mice during atherosclerosis development.Further work is required to better understand the pro-inflammatory and proteolytic mechanisms involved in decorin/collagen remodelling in the plaques of ApoE KO mice and the ultimate effects of these events on atherosclerosis disease progression. This evidence concerns the gene APOE and atherosclerosis.