VEGFR2 was detected in PCa metastases with very strong evidence of higher immunoreactivity in BM compared to primary PCa (mean staining index primary PCa: 0.10, 95% CI 0.07–0.14; BM: 0.25, 95% CI 0.19–0.31; P=0.0001); see Figure 1. Here, KDR is linked to posterior cortical atrophy.