MAPT and Alzheimer disease: In addition, they showed by co-immunoprecipitation techniques that BIN1 interacts with Tau in synaptosomal fractions from mouse brain homogenates, however they did not detect any colocalisation of BIN1 with neurofibrillary tangles by immunohistochemical analysis in the brain of AD cases, suggesting that BIN1 probably does not have a role in the late stages of tangle formation although it could affect tau aggregation and/or oligomer formation in earlier stages of disease [12].