VWF and Schnyder corneal dystrophy: Similarly, VWF enhanced the adhesiveness of sickled erythrocytres to the endothelium in vitro [29,30], suggesting its involvement in the vasoocclusive pathophysiology of SCD, although the evidence of a role in vivo in contributing to specific clinical complications, whether in the macro or the microcirculation, is still limited (10) and needs further investigation.