STIM1 and dilated cardiomyopathy: Although clearance of Tam from serum is faster in mice than humans, accumulation of Tam and its metabolites in tissues are significantly elevated 24 hours after 5 daily doses of 40 mg/kg [43], making Tam-induced effects on cardiac myocyte function a potential contributor to the transient dilated cardiomyopathy seen in the Tg(αMHC-MerCreMer) mouse model.