The IL-10 gene is situated in a major SLE susceptibility locus (1q31-32), however, in spite of the considerable number of studies performed, no definitive result about its involvement on SLE susceptibility was achieved [33], which could be due, at least in part, to the differences in the frequencies of the IL-10 rs1800896 alleles among populations. Here, IL10 is linked to systemic lupus erythematosus.