In view of the relationship between presence of the Atg5 T* mutated allele and high IL-10 serum levels in SLE patients, and given the reported association of the IL-10 rs1800896 G* allele with high IL-10 production [34], we wanted to evaluate the possible effect of both Atg5 and IL-10 SNPs, alone or in combination, on SLE susceptibility. This evidence concerns the gene ATG5 and systemic lupus erythematosus.