It is of note, Alonso-Perez et al. [26] showed that this Atg5 SNP was more associated with SLE susceptibility in Central than in Southern Europeans (OR, 95% CI: 1.36, 1.10-1.68 and 1.11, 0.98-1.26 , respectively), in accordance with the frequency of genetically high IL-10 producers reported in these populations. This evidence concerns the gene ATG5 and systemic lupus erythematosus.