Accordingly, the presence of the high IL-10 producer allele was a risk factor for SLE in carriers of the Atg5 mutation (OR, 95% CI: 2.19, 1.05-4.57; p=0.04) but not in Atg5 wild type individuals (OR, 95% CI: 0.54, 0.27-1.1; p=0.09). This evidence concerns the gene IL10 and systemic lupus erythematosus.