Serum levels of IFNα and TNFα were significantly higher in patients compared with controls [IFNα: 19.61 (44.61) vs 9.91 (11.52), p<0.001; TNFα: 41.26 (113.56) vs 18.83 (49.52), p=0.02], whereas IL-10 were detected in SLE patients [0.23 (2.84)] but not in most healthy individuals. This evidence concerns the gene TNF and systemic lupus erythematosus.