Several of the identified mGISTIC regions harbored known or putative adenocarcinoma driver candidates, such as EGFR, MDM2, KRAS, MYC, TERT, MET, CCND1, NKX2-1/TITF1, CDK4, ERBB2, ID1, RB1, CDKN2A and PTEN. The gene discussed is RB1; the disease is adenocarcinoma.