CD8A and malaria: Lastly, our finding via depletion studies that the majority of malaria-specific T-cell responses enhanced by 7DW8-5 are of CD8+ T cells is truly encouraging in light of the fact that, to date, there has been no single adjuvant that can potently enhance a vaccine-induced CD8+ T-cell response or one that can enhance the immunogenicity of viral-vectored vaccines.