Ndisang and Jadhav have demonstrated that administration of hemin up-regulates HO activity in non-obese insulin-resistant Goto-Kakizaki rats via induction of HO-1 and that the anti-diabetic effect of heme is abrogated by concurrent administration of an inhibitor of HO activity, chromium (III) mesoporphyrin IX chloride (CrMP) [3]. This evidence concerns the gene HMOX1 and Insulin resistance.