RSPO1 stimulation of LGR4 potentiates Wnt signaling which is generally oncogenic [13-15,37], and overexpression of RSPO2 and RSPO3 is associated with carcinogenesis in human colon cancer as well as in mouse models of breast and colon cancer [20,38-40]. Here, RSPO2 is linked to malignant colon neoplasm.