The subclinical characteristics of the Vietnamese HBsAg-positive patients confirmed previous reports showing acceleration of severe HBV/HDV-associated liver disease by approx. 2-fold increase in serum aminotransferases (ALT and AST) and total and direct bilirubin in HDV-RNA positive compared to HDV-RNA negative patients (p<0.001) (Figure 4) [53]. The gene discussed is GPT; the disease is liver disorder.