IFIH1 and viral infectious disease: An indirect mechanism for this effect has recently been proposed by Xu et al. [20], who showed that viral infection induces translocation of gC1qR/p32 to the mitochondria where it blocks a mitochondrial intermediate in the innate antiviral response pathway mediated by the RNA helicases RIG1 (retinoic-acid-inducible protein 1) and MDA5 (melanoma differentiation-associated gene 5), which are members of the Rig1-like receptor (RLR) class.