TNF and infarction: Zheng SY et al. [24] also reported that SFI can remarkablely inhibit the rise in MDA and lactate dehydrogenase (LDH) and as well as creatine kinase (CK), increase SOD activity, reduce the size of infarction, improve the pathologic changes of myocardium and inhibit NF-κB activity leading to down-regulation of pro-inflammatory cytokine (TNF-α and IL-6) expression during I/R [25].