Similarly, an inhibitory role for BTLA and HVEM has been reported in the Con-A induced hepatitis model [12], and we found previously that the HVEM-BTLA interaction is also critical to prevent severe disease and destructive inflammatory immune responses in a colitis model induced by the transfer of naïve CD4+ T cells into Rag−/− mice [13]. The gene discussed is BTLA; the disease is colitis.