CD8A and infection: To extend these observations, naïve (CD44low) OT-I CD8 T cells expressing a transgenic TCR (Vα2Vβ5) specific for H-2Kb/OVA257–264 were transferred into WT mice, and HVEM expression was monitored after infection with recombinant VACV-WR expressing the full length OVA protein (rVACV-WR-OVA) (Figure 2).