A switch from oxidative to glycolytic muscle is reported to occur in patients with type 2 diabetes [38], so this elevated glycolytic muscle phenotype for aged CHC22-mice is consistent with their development of symptoms of type 2 diabetes (hyperglycemia and sequestration of intracellular GLUT4) by 20 weeks of age [1]. The gene discussed is SLC2A4; the disease is Hyperglycemia.