However, genetic Bim deficiency, which can restore the T cell compartment in the case of IL-7R deficiency [45] was reported not to prevent lymphopenia caused by the GIMAP5 sphinx mutation [15] and further difficulty for the simple apoptosis model arose from a thorough examination of GIMAP5 expression in mouse, rat and human cells which revealed that it is located not on mitochondria but on lysosomes and multivesicular bodies [24]. The gene discussed is IL7R; the disease is lymphopenia.