IL13RA2 and central nervous system cancer: Interestingly, in parallel with what is seen for IL13Rα2, mesenchymal signature genes are also up-regulated in high-grade gliomas (WHO IV vs. III/II/I: 93 of 211 signature genes; 44.1%) (Figure S6B in File S1), and proneural signature genes are commonly down-regulated in high-grade tumors (WHO IV vs. III/II/I: 59 of 171 signature genes; 34.5%) (Figure S6B in File S1).