The high associations of IL13Rα2-related pathways as defined by IPA analysis with immune system functions are consistent with previous reports of elevated immune activation in mesenchymal-subtype tumors [37], and suggests that IL13Rα2 over-expression in other glioma subtypes (Figure S4 in File S1) may be an indicator of on-going immune processes in these tumors as well. This evidence concerns the gene IL13RA2 and glioma.