Focusing on IL13Rα2, a clinically relevant glioma target being pursued for therapeutic development [11,28,39-41], we have taken a bioinformatics approach to better understand the intrinsic biology of tumors with high IL13Rα2 expression, and to gain insight into how this may affect inter-patient IL13Rα2 heterogeneity in gliomas. This evidence concerns the gene IL13RA2 and glioma.