When fluorescein-TFF3 (50 ng/g of body weight) was administered intravenously to mice with 24-hr cerebral ischemia/reperfusion injury, fluorescein-TFF3 extravasation was found in the ischemic brain tissue, but not in the intact brain tissue, within 1 hr following administration (Figure 3C). The gene discussed is TFF3; the disease is brain ischemia.