TFF3 and brain ischemia: The neuroprotective action of TFF3 is supported by several lines of evidence, including TFF3 upregulation in the hepatocyte in response to cerebral ischemia/reperfusion injury, intensification of cerebral injury and deterioration of the forelimb motor function in TFF3-/- mice, and reversal of TFF3 deficiency-induced cerebral changes by administration of recombinant TFF3 in cerebral ischemia/reperfusion injury.