CD4 and arthritic joint disease: Thus, we determined the percent frequency of Th17 (CD4+IL-17+) and Treg (CD4+Foxp3+) cells in CD4+ T cells isolated from the spleen or the inguinal lymph nodes of CIA mice that were treated with or without varying modified allo-tDCs on day 21 following the onset of arthritis (Figure 5C).