In the caspase family, caspase-1, caspase-3, caspase-6, and caspase-9 are major cascade activation proteins, and PDT initiates the apoptosis cascade reaction primarily by activating caspase-dependent intrinsic and extrinsic pathways; this cleaves PARP, ultimately leading to apoptosis of tumor cells [24]. Here, CASP3 is linked to neoplasm.