This result, in combination with results for PD and PDD, suggests the possibility that reduced SMG1 expression, which can clearly drive elevations to t-syn and p-syn in vitro, may be functionally relevant to the etiology of synucleinopathies in vivo, and suggests that further studies are warranted to delineate potential contributions of SMG1 function in synucleinopathies. The gene discussed is SMG1; the disease is synucleinopathy.