SNCA and Parkinson disease: The importance of p-Syn in the pathogenesis of synucleinopathies is further strengthened by genetic findings showing that point mutations in the SNCA gene [2], [3], [4] and SNCA locus duplication and triplication [5], [6], [7] cause autosomal dominant forms of PD that manifest with neuropathological features in common with sporadic PD, including the presence of Lewy bodies with p-Syn aggregates.