SMG1 and Parkinson disease: This result, in combination with results for PD and PDD, suggests the possibility that reduced SMG1 expression, which can clearly drive elevations to t-syn and p-syn in vitro, may be functionally relevant to the etiology of synucleinopathies in vivo, and suggests that further studies are warranted to delineate potential contributions of SMG1 function in synucleinopathies.