TNF and acute respiratory distress syndrome: Finally, it was observed that both the AM281 and/or AM630 treatments attenuated the JZL184-induced actions on the following pro-inflammatory cytokine/chemokine concentrations measured in the BAL 6, 24 or 48 hours after LPS-induced ALI: TNF- α (KW = 13.33, 24 hours and KW = 21.05, 48 hours after LPS instillation) (Figure 11A), IL-6 (KW = 13.27, 6 hours, KW = 19.80, 24 hours and KW = 22.02, 48 hours after LPS instillation) (Figure 11B) and MCP-1 (KW = 20.43, 6 hours and KW = 19.10, 48 hours after LPS instillation) (Figure 11C).