Neither a statistically significant result was obtained applying a Cox regression model to estimate the influence of the SMAD3 rs17228212 genetic variant on risk of CV disease, which was adjusted for sex, age at the time of RA diagnosis, and traditional CV risk factors as potential confounders: HR [95%CI]=0.93 [0.74-1.18], p=0.56. The gene discussed is SMAD3; the disease is rheumatoid arthritis.