UGT1A1 and cholelithiasis: The coinheritance of UGT1A1 polymorphism (7/7 or 6/7 repeat) and SCA was found to potentially increase the risk of developing cholelithiasis (OR = 5.44). We further assessed the global frequency of the genotype distribution of UGT1A1 promoter polymorphism according to the location on the various continents (Table 5) [9], [11]–[35].