MAPK8 and rheumatoid arthritis: As shown in Figure 7, triptolide markedly diminished the activation of IL1-β-induced ERK (P<0.01 or P<0.001), p38 (P<0.05 or P<0.001) and JNK (P<0.01 or P<0.001), which are associated with survival, migration and adhesion of HFLS–RA cells.