VEGFA and rheumatoid arthritis: Regarding to their antiangiogenic effects, DMARDs such as methotrexate (MTX), sulphasalazine (SASP) and penicillamine have been shown to inhibit angiogenesis in experimental systems [5]; Bucillamine (BUC) and gold sodium thiomalate (GST) have been demonstrated to inhibit vascular endothelial growth factor (VEGF) production [6]; Infliximab, cyclosporin and endostatin also might be attributable to the downregulation of VEGF and RA-associated angiogenesis [7].