We have previously demonstrated that triptolide may exert chondroprotective and anti-inflammatory effects in RA by the direct suppression of the production of MMPs and the simultaneous up-regulation of TIMPs production in the joints of CIA mice [20]–[21], and also may prevent the bone destruction and inhibit osteoclast formation by regulating RANKL/RANK/OPG signal pathway [22]. This evidence concerns the gene TNFSF11 and rheumatoid arthritis.